GLUTATHIONE 1500mg

Overview

Glutathione (GSH) is a naturally occurring tripeptide composed of glutamine, glycine, and cysteine. It is synthesized endogenously in the liver and is present in virtually every cell of the human body. Glutathione is the primary intracellular antioxidant and serves as the foundation of the body's broader antioxidant network. Endogenous levels decline with age by approximately 30–50% between young adulthood and older age, and are further depleted by oxidative stress, chronic illness, toxin exposure, and poor nutrition.

Mechanism of Action

Glutathione neutralizes free radicals and reactive oxygen species (ROS) by donating electrons via its sulfhydryl group. It regenerates oxidized vitamins C and E back to their active forms through the glutathione-ascorbate cycle, maintains the intracellular GSH/GSSG redox ratio, supports phase-II hepatic detoxification pathways, and modulates immune signaling. It also inhibits tyrosinase activity, which influences melanin synthesis.

Research and Off-Label Applications

Cellular antioxidant defense and oxidative stress reduction, hepatic detoxification and liver support, skin brightening and pigmentation modulation, immune function enhancement, neuroprotection and potential role in neurodegenerative conditions, post-chemotherapy recovery support, and general anti-aging and longevity protocols.

Administration

Oral bioavailability is poor due to gastrointestinal degradation of the tripeptide. Clinically meaningful systemic elevation is most reliably achieved via intravenous (IV) infusion, intramuscular (IM), or subcutaneous injection. Plasma half-life of reduced GSH is approximately 14 minutes; cellular effects accumulate with consistent administration over 4–8 week cycles. Liposomal oral formulations offer improved but still variable bioavailability.

Potential Adverse Effects

Generally well tolerated when administered appropriately. Serious adverse events include rare anaphylaxis and potential hepatotoxicity, particularly with intravenous use at non-standardized doses. Long-term use may reduce zinc levels. May worsen asthma in susceptible individuals if inhaled. Should not be used concurrently with chemotherapy without oncologist approval, as it may interfere with treatment efficacy. Quality and sterility of the source compound are critical safety considerations.